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ALNY stock logo

ALNY

Alnylam Pharmaceuticals, Inc.

$205.52
0.04
 (0.02%)
Exchange:  NASDAQ
Market Cap:  27.44B
Shares Outstanding:  331341
Delayed data
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Overview
Earnings
Financials
Valuation
Chart

About The Company

Sector:  Healthcare
Industry:  Biotechnology
   
CEO:  Yvonne L. Greenstreet
Full Time Employees:  2500
Address: 
675 West Kendall Street
Cambridge
MA
2142
US
Website:  https://www.alnylam.com
Alnylam Pharmaceuticals, Inc. is a biopharmaceutical company primarily dedicated to the discovery, development, and commercialization of innovative therapeutic solutions leveraging ribonucleic acid interference (RNAi) technology. Its robust pipeline of RNAi-based treatments addresses a range of critical therapeutic areas, including inherited genetic disorders, cardio-metabolic conditions, hepatic infectious diseases, and central nervous system (CNS) and ocular disorders. Currently, Alnylam offers several approved therapies: ONPATTRO (patisiran) for adults suffering from polyneuropathy associated with hereditary transthyretin-mediated amyloidosis; GIVLAARI for adult patients with acute hepatic porphyria (AHP); and OXLUMO (lumasiran) for primary hyperoxaluria type 1 (PH1). Beyond its commercial portfolio, the company maintains an active development pipeline. Key investigational therapies include givosiran, aimed at adolescent patients with AHP; patisiran, being explored for transthyretin amyloidosis (ATTR) with cardiomyopathy; cemdisiran for complement-mediated disorders; ALN-AAT02 for AAT deficiency-associated liver disease; ALN-HBV02 for chronic hepatitis B virus infection; Zilebesiran for hypertension; and ALN-HSD for non-alcoholic steatohepatitis (NASH). Additionally, other candidates such as Fitusiran for hemophilia and bleeding disorders, Inclisiran for hypercholesterolemia, an expanded indication for lumasiran for advanced PH1 and recurrent kidney stones, and vutrisiran for ATTR amyloidosis (currently in Phase 3 clinical trials) are also progressing. Alnylam also engages in strategic alliances with other pharmaceutical leaders. Notable collaborations include those with Regeneron Pharmaceuticals, Inc., focused on discovering and developing RNAi therapeutics for ocular and CNS targets, and with Sanofi Genzyme for broader RNAi therapeutic development and commercialization efforts. Further licensing and partnership agreements are in place with entities such as Novartis AG, Vir Biotechnology, Inc., Dicerna Pharmaceuticals, Inc., Ionis Pharmaceuticals, Inc., and PeptiDream, Inc. Established in 2002, Alnylam Pharmaceuticals maintains its corporate headquarters in Cambridge, Massachusetts.

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Revenue Segmentation

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EPS

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Earnings Call

Full text

Earnings transcript

Read the complete earnings call transcript.

AI summary

Key takeaways

Short, structured highlights from the call so you can focus on what matters.

2026/04/30 — Q1 quarter 2026

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Income Statement
Balance Sheet
Cash Flow Statement
Analyst Estimates

Income Statement

Year202320242025
Revenue1,828,2922,248,2433,713,937
Gross Profit1,517,8861,924,8733,036,771
EBITDA-258,242-178,847631,437
Operating Income-282,175-176,885501,578
Net Income-440,242-278,157313,747

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(* All numbers are in thousands)

Balance Sheet

Year202320242025
Total Assets3,829,8804,239,9834,966,331
Total Liabilities4,050,5244,172,8954,177,155
Total Stockholders Equity-220,64467,088789,176
Total Debt1,305,3871,296,0482,968,798
Cash and Cash Equivalents812,688966,4281,657,250

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Cash Flow Statement

Year202320242025
Operating Cash Flow104,156-8,312524,080
Capital Expenditure-62,211-34,277-58,697
Free Cash Flow41,945-42,589465,383
Net Income-440,242-278,157313,747
Net Change in Cash-53,672153,768690,155

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(* All numbers are in thousands)

Analyst Estimates

Fiscal Year2030Research AccessResearch AccessResearch AccessResearch Access
Estimated Revenue (Low)10,639,979.327Research AccessResearch AccessResearch AccessResearch Access
Estimated Revenue (High)13,286,994.450Research AccessResearch AccessResearch AccessResearch Access
Estimated Revenue (Avg)11,719,300Research AccessResearch AccessResearch AccessResearch Access
Estimated Ebitda (Low)-4,590,615.055Research AccessResearch AccessResearch AccessResearch Access
Estimated Ebitda (High)-3,676,079.603Research AccessResearch AccessResearch AccessResearch Access
Estimated Ebitda (Avg)-4,048,981.522Research AccessResearch AccessResearch AccessResearch Access
Estimated Net Income (Low)2,238,091.184Research AccessResearch AccessResearch AccessResearch Access
Estimated Net Income (High)2,984,640.561Research AccessResearch AccessResearch AccessResearch Access
Estimated Net Income (Avg)2,542,497.228Research AccessResearch AccessResearch AccessResearch Access
Estimated SGA Expense (Low)5,688,237.324Research AccessResearch AccessResearch AccessResearch Access
Estimated SGA Expense (High)7,103,357.575Research AccessResearch AccessResearch AccessResearch Access
Estimated SGA Expense (Avg)6,265,252.743Research AccessResearch AccessResearch AccessResearch Access
Estimated EPS (Avg)18.880Research AccessResearch AccessResearch AccessResearch Access
Estimated EPS (High)22.160Research AccessResearch AccessResearch AccessResearch Access
Estimated EPS (Low)16.620Research AccessResearch AccessResearch AccessResearch Access
Number of Analysts (Estimated Revenue)16Research AccessResearch AccessResearch AccessResearch Access
Number of Analysts (Estimated EPS)6Research AccessResearch AccessResearch AccessResearch Access

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(* All numbers are in thousands)

Current Key Metrics

?Revenue
 (TTM)
: 
2.248B  ?P/S
 (TTM)
: 
5.72
?Net Income
 (TTM)
: 
-278157000  ?P/E
 (TTM)
: 
33.69
?Enterprise Value
 (TTM)
: 
27.06B  ?EV/FCF
 (TTM)
: 
49.88
?Dividend Yield
 (TTM)
: 
0%  ?Payout Ratio
 (TTM)
: 
0%
?ROE
 (TTM)
: 
93.61%  ?ROIC
 (TTM)
: 
22.74%
?Net Debt
 (TTM)
: 
48.915M  ?Debt/Equity
 (TTM)
: 
0.94
?P/B
 (TTM)
: 
20.22  ?Current Ratio
 (TTM)
: 
3.05

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Forward P/E Ratios

?

Forward P/E (Avg EPS estimate) — log in with Research Access for high/low estimates and the interactive table.

Forward P/E 1YResearch AccessResearch AccessResearch AccessResearch Access
27.29Research AccessResearch AccessResearch AccessResearch Access

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SWOT Analysis

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At what price to buy it? -
Intrinsic Value Calculator

This is an automatic estimate. The most reliable way to know fair value for your own assumptions is to run the calculator below.

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Common questions about ALNY valuation

Is Alnylam Pharmaceuticals, Inc. (ALNY) overvalued or undervalued right now?

MARKETSnap estimates intrinsic value for Alnylam Pharmaceuticals, Inc. (ALNY) using its proprietary valuation methodology, which incorporates discounted cash flow (DCF) analysis together with long-term earnings and fundamentals assumptions. By comparing intrinsic value to the current market price, long-term investors can see whether the stock screens as potentially overvalued, fairly valued, or undervalued today.

Is ALNY a buy, hold, or sell for long-term investors?

MARKETSnap does not give one-word “buy” or “sell” calls. Instead, it shows whether ALNY trades at a premium or discount to its estimated intrinsic value, how sensitive that value is to growth and margin assumptions, and how the stock fits into a diversified, long-term portfolio so investors can make their own buy, hold, or sell decision.

What is ALNY’s P/E ratio?

You can see ALNY’s trailing P/E (TTM) and forward P/E estimates in the Current Key Metrics and Forward P/E Ratios sections above. The P/E ratio compares the current share price to earnings per share and helps investors gauge valuation relative to earnings.

How is intrinsic value calculated for ALNY?

MARKETSnap uses its own valuation framework—not a generic spreadsheet DCF alone. Future cash flows and earnings are projected, discounted, and combined with MARKETSnap’s methodology so intrinsic value reflects fundamentals and long-term assumptions. You can run your own inputs and see the result using the Intrinsic Value Calculator above.

Is ALNY a good long-term investment?

Whether ALNY fits a long-term portfolio depends on your assumptions about growth, margins, and risk. MARKETSnap provides the metrics, intrinsic value calculator, and SWOT context so you can form your own view rather than rely on a single buy/sell rating.

ALNY

1-day price chart preview. Log in for 1W through 5Y ranges and period tabs.

Daily snapshot

0.02
MARKETSnap

Trading Metrics:

Open: 205.07   Previous Close: 205.48
Day Low: 200.11   Day High: 207.99
Year Low: 197.81   Year High: 495.55
Price Avg 50: 289.9   Price Avg 200: 350.59
Volume: 4.461M   Average Volume: 1.463M

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See in Nexus

Relevant news

Securities Fraud Investigation Into Alnylam Pharmaceuticals, Inc. (ALNY) Announced – Shareholders Who Lost Money Urged To Contact Glancy Prongay Wolke & Rotter LLP, a Leading Securities Fraud Law Firm
30-07-2026 17:15
Securities Fraud Investigation Into Alnylam Pharmaceuticals, Inc. (ALNY) Announced – Shareholders Who Lost Money Urged To Contact Glancy Prongay Wolke & Rotter LLP, a Leading Securities Fraud Law Firm
Alnylam Pharmaceuticals, Inc. (ALNY) Shareholders Who Lost Money – Contact Law Offices of Howard G. Smith About Securities Fraud Investigation
30-07-2026 16:57
Securities Fraud Investigation Into Alnylam Pharmaceuticals, Inc. (ALNY) Announced – Shareholders Who Lost Money Urged To Contact The Law Offices of Frank R. Cruz
Alnylam Pharmaceuticals, Inc. (ALNY) Shareholders Who Lost Money – Contact Law Offices of Howard G. Smith About Securities Fraud Investigation
30-07-2026 16:57
Securities Fraud Investigation Into Alnylam Pharmaceuticals, Inc. (ALNY) Announced – Shareholders Who Lost Money Urged To Contact The Law Offices of Frank R. Cruz
Alnylam Pharmaceuticals Q2 Earnings Call Highlights
30-07-2026 10:06
Alnylam Pharmaceuticals Q2 Earnings Call Highlights
Unlocking Q2 Potential of Alnylam (ALNY): Exploring Wall Street Estimates for Key Metrics
28-07-2026 10:15
Unlocking Q2 Potential of Alnylam (ALNY): Exploring Wall Street Estimates for Key Metrics
Andra AP fonden Raises Holdings in Alnylam Pharmaceuticals, Inc. $ALNY
21-07-2026 03:19
Andra AP fonden Raises Holdings in Alnylam Pharmaceuticals, Inc. $ALNY

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