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ALNY stock logo

ALNY

Alnylam Pharmaceuticals, Inc.

$316.09
-1.27
 (-0.4%)
Exchange:   NASDAQ
Market Cap:   41.921B
Shares Outstanding:   331341
Overview
Earnings
Financials
Valuation
Chart

About The Company

Sector:  Healthcare
Industry:  Biotechnology
   
CEO:  Yvonne L. Greenstreet
Full Time Employees:  2230
Address: 
675 West Kendall Street
Cambridge
MA
2142
US
Website:  https://www.alnylam.com
Alnylam Pharmaceuticals, Inc., a biopharmaceutical company, focuses on discovering, developing, and commercializing novel therapeutics based on ribonucleic acid interference. The company’s pipeline of investigational RNAi therapeutics focuses on genetic medicines, cardio-metabolic diseases, hepatic infectious diseases, and central nervous system (CNS)/ocular diseases. Its marketed products include ONPATTRO (patisiran), a lipid complex injection for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; GIVLAARI for the treatment of adults with acute hepatic porphyria (AHP); and OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1 (PH1). In addition, the company is developing givosiran for the treatment of adolescent patients with AHP; patisiran for the treatment of transthyretin amyloidosis, or ATTR amyloidosis, with cardiomyopathy; cemdisiran to treat complement-mediated diseases; ALN-AAT02 for the treatment of AAT deficiency-associated liver disease; ALN-HBV02 to treat chronic HBV infection; Zilebesiran to treat hypertension; and ALN-HSD to treat NASH. Further, it offers Fitusiran for the treatment of hemophilia and rare bleeding disorders, Inclisiran to treat hypercholesterolemia, lumasiran for the treatment of advanced PH1 and recurrent renal stones, and vutrisiran for the treatment of ATTR amyloidosis, which is in phase 3 clinical trial. Alnylam Pharmaceuticals, Inc. has strategic collaborations with Regeneron Pharmaceuticals, Inc. to discover, develop, and commercialize RNAi therapeutics for a range of diseases by addressing therapeutic targets expressed in the eye and CNS; and Sanofi Genzyme to discover, develop, and commercialize RNAi therapeutics. It also has license and collaboration agreements with Novartis AG; Vir Biotechnology, Inc.; Dicerna Pharmaceuticals, Inc.; Ionis Pharmaceuticals, Inc.; and PeptiDream, Inc. The company was founded in 2002 and is headquartered in Cambridge, Massachusetts.

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Revenue Segmentation

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EPS

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Earnings Call

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Earnings transcript

Read the complete earnings call transcript.

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Key takeaways

Short, structured highlights from the call so you can focus on what matters.

2025/05/01 — Q1 quarter 2025

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Income Statement
Balance Sheet
Cash Flow Statement
Analyst Estimates

Income Statement

Year202320242025
Revenue1,828,2922,248,2433,713,937
Gross Profit1,517,8861,924,8733,036,771
EBITDA-258,242-178,847557,236
Operating Income-282,175-176,885501,578
Net Income-440,242-278,157313,747

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(* All numbers are in thousands)

Balance Sheet

Year202320242025
Total Assets3,829,8804,239,9834,966,331
Total Liabilities4,050,5244,172,8954,177,155
Total Stockholders Equity-220,64467,088789,176
Total Debt1,305,3871,296,0482,968,798
Cash and Cash Equivalents812,688966,4281,657,250

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Cash Flow Statement

Year202320242025
Operating Cash Flow104,156-8,312524,080
Capital Expenditure-62,211-34,277-58,697
Free Cash Flow41,945-42,589465,383
Net Income-440,242-278,157313,747
Net Change in Cash-53,672153,768690,155

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(* All numbers are in thousands)

Analyst Estimates

Fiscal Year2030Full AccessFull AccessFull AccessFull Access
Estimated Revenue (Low)10,315,171.419Full AccessFull AccessFull AccessFull Access
Estimated Revenue (High)13,379,743.289Full AccessFull AccessFull AccessFull Access
Estimated Revenue (Avg)11,356,233.333Full AccessFull AccessFull AccessFull Access
Estimated Ebitda (Low)-4,676,122.449Full AccessFull AccessFull AccessFull Access
Estimated Ebitda (High)-3,605,076.988Full AccessFull AccessFull AccessFull Access
Estimated Ebitda (Avg)-3,968,920.515Full AccessFull AccessFull AccessFull Access
Estimated Net Income (Low)2,279,237.146Full AccessFull AccessFull AccessFull Access
Estimated Net Income (High)3,187,012.700Full AccessFull AccessFull AccessFull Access
Estimated Net Income (Avg)2,587,616.369Full AccessFull AccessFull AccessFull Access
Estimated SGA Expense (Low)5,514,591.830Full AccessFull AccessFull AccessFull Access
Estimated SGA Expense (High)7,152,942.014Full AccessFull AccessFull AccessFull Access
Estimated SGA Expense (Avg)6,071,153.742Full AccessFull AccessFull AccessFull Access
Estimated EPS (Avg)19.210Full AccessFull AccessFull AccessFull Access
Estimated EPS (High)23.660Full AccessFull AccessFull AccessFull Access
Estimated EPS (Low)16.920Full AccessFull AccessFull AccessFull Access
Number of Analysts (Estimated Revenue)9Full AccessFull AccessFull AccessFull Access
Number of Analysts (Estimated EPS)14Full AccessFull AccessFull AccessFull Access

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(* All numbers are in thousands)

Current Key Metrics

?Revenue
 (TTM)
: 
2.248B  ?P/S
 (TTM)
: 
11.33
?Net Income
 (TTM)
: 
-278157000  ?P/E
 (TTM)
: 
133.75
?Enterprise Value
 (TTM)
: 
41.71B  ?EV/FCF
 (TTM)
: 
89.63
?Dividend Yield
 (TTM)
: 
0  ?Payout Ratio
 (TTM)
: 
0
?ROE
 (TTM)
: 
0.9  ?ROIC
 (TTM)
: 
0.14
?Net Debt
 (TTM)
: 
48.915M  ?Debt/Equity
 (TTM)
: 
1.62
?P/B
 (TTM)
: 
53.18  ?Current Ratio
 (TTM)
: 
2.76

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Forward P/E Ratios

?

Forward P/E (Avg EPS estimate) — log in with Full Access for high/low estimates and the interactive table.

Forward P/E 1YFull AccessFull AccessFull AccessFull Access
41.98Full AccessFull AccessFull AccessFull Access

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SWOT Analysis

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Intrinsic Value Calculator

This is an automatic estimate. The most reliable way to know fair value for your own assumptions is to run the calculator below.


Calculate ALNY Intrinsic Value

Common questions about ALNY valuation

Is Alnylam Pharmaceuticals, Inc. (ALNY) overvalued or undervalued right now?

MARKETSnap estimates intrinsic value for Alnylam Pharmaceuticals, Inc. (ALNY) using its proprietary valuation methodology, which incorporates discounted cash flow (DCF) analysis together with long-term earnings and fundamentals assumptions. By comparing intrinsic value to the current market price, long-term investors can see whether the stock screens as potentially overvalued, fairly valued, or undervalued today.

Is ALNY a buy, hold, or sell for long-term investors?

MARKETSnap does not give one-word “buy” or “sell” calls. Instead, it shows whether ALNY trades at a premium or discount to its estimated intrinsic value, how sensitive that value is to growth and margin assumptions, and how the stock fits into a diversified, long-term portfolio so investors can make their own buy, hold, or sell decision.

What is ALNY’s P/E ratio?

You can see ALNY’s trailing P/E (TTM) and forward P/E estimates in the Current Key Metrics and Forward P/E Ratios sections above. The P/E ratio compares the current share price to earnings per share and helps investors gauge valuation relative to earnings.

How is intrinsic value calculated for ALNY?

MARKETSnap uses its own valuation framework—not a generic spreadsheet DCF alone. Future cash flows and earnings are projected, discounted, and combined with MARKETSnap’s methodology so intrinsic value reflects fundamentals and long-term assumptions. You can run your own inputs and see the result using the Intrinsic Value Calculator above.

Is ALNY a good long-term investment?

Whether ALNY fits a long-term portfolio depends on your assumptions about growth, margins, and risk. MARKETSnap provides the metrics, intrinsic value calculator, and SWOT context so you can form your own view rather than rely on a single buy/sell rating.

ALNY

1-day price chart preview. Log in for 1W through 5Y ranges and period tabs.

-0.4
MARKETSnap

Trading Metrics:

Open: 319.32   Previous Close: 317.36
Day Low: 314.21   Day High: 321.76
Year Low: 205.87   Year High: 495.55
Price Avg 50: 337.9   Price Avg 200: 392.53
Volume: 1.196M   Average Volume: 1.343M

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See in Nexus

Relevant news

Alnylam Pharmaceuticals, Inc. $ALNY Shares Bought by Anchor Investment Management LLC
16-03-2026 03:26
Alnylam Pharmaceuticals, Inc. $ALNY Shares Bought by Anchor Investment Management LLC
Analysts Set Alnylam Pharmaceuticals, Inc. (NASDAQ:ALNY) Price Target at $477.96
09-03-2026 02:54
Analysts Set Alnylam Pharmaceuticals, Inc. (NASDAQ:ALNY) Price Target at $477.96
Tenaya Therapeutics inks $1.13 billion deal with Alnylam for heart-disease treatments
05-03-2026 09:10
Tenaya Therapeutics inks $1.13 billion deal with Alnylam for heart-disease treatments
Alnylam Pharmaceuticals, Inc. (ALNY) Presents at TD Cowen 46th Annual Health Care Conference Transcript
02-03-2026 16:07
Alnylam Pharmaceuticals, Inc. (ALNY) Presents at TD Cowen 46th Annual Health Care Conference Transcript
Aberdeen Group plc Sells 61,228 Shares of Alnylam Pharmaceuticals, Inc. $ALNY
16-02-2026 03:16
Aberdeen Group plc Sells 61,228 Shares of Alnylam Pharmaceuticals, Inc. $ALNY
Alnylam Hit Hard As Investors Forced To Revise Future Profit Expectations
13-02-2026 15:07
Alnylam Hit Hard As Investors Forced To Revise Future Profit Expectations

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