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SYRE stock logo

SYRE

Spyre Therapeutics, Inc.

$
 (%)
[ms_data_label text=’Delayed data’]
Exchange:  NASDAQ
Market Cap:  
Shares Outstanding:  391669
Overview
Earnings
Financials
Valuation
Chart

About The Company

Sector:  Healthcare
Industry:  Biotechnology
   
CEO:  Cameron Turtle
Full Time Employees:  73
Address: 
221 Crescent Street
Waltham
MA
2453
US
Website:  https://www.spyre.com
Spyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn’s disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts.

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Revenue Segmentation

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EPS

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Earnings Call

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Income Statement
Balance Sheet
Cash Flow Statement
Analyst Estimates

Income Statement

Year202320242025
Revenue88600
Gross Profit8860-171,653
EBITDA-127,600-207,967-209,562
Operating Income-242,303-208,566-209,562
Net Income-338,790-208,018-155,203

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(* All numbers are in thousands)

Balance Sheet

Year202320242025
Total Assets341,859608,484777,781
Total Liabilities157,84390,68062,545
Total Stockholders Equity184,016517,804715,236
Total Debt84,55500
Cash and Cash Equivalents188,89389,42385,721

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(* All numbers are in thousands)

Cash Flow Statement

Year202320242025
Operating Cash Flow-99,910-157,410-169,252
Capital Expenditure000
Free Cash Flow-99,910-157,410-169,252
Net Income-338,790-208,018-155,203
Net Change in Cash152,799-99,792-3,702

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(* All numbers are in thousands)

Analyst Estimates

Fiscal Year2030Full AccessFull AccessFull AccessFull Access
Estimated Revenue (Low)105,074.565Full AccessFull AccessFull AccessFull Access
Estimated Revenue (High)105,074.565Full AccessFull AccessFull AccessFull Access
Estimated Revenue (Avg)105,074.565Full AccessFull AccessFull AccessFull Access
Estimated Ebitda (Low)-21,014.912Full AccessFull AccessFull AccessFull Access
Estimated Ebitda (High)-21,014.912Full AccessFull AccessFull AccessFull Access
Estimated Ebitda (Avg)-21,014.912Full AccessFull AccessFull AccessFull Access
Estimated Net Income (Low)-1,349,897.325Full AccessFull AccessFull AccessFull Access
Estimated Net Income (High)-1,349,897.325Full AccessFull AccessFull AccessFull Access
Estimated Net Income (Avg)-1,349,897.325Full AccessFull AccessFull AccessFull Access
Estimated SGA Expense (Low)1,277,579.978Full AccessFull AccessFull AccessFull Access
Estimated SGA Expense (High)1,277,579.978Full AccessFull AccessFull AccessFull Access
Estimated SGA Expense (Avg)1,277,579.978Full AccessFull AccessFull AccessFull Access
Estimated EPS (Avg)-3.900Full AccessFull AccessFull AccessFull Access
Estimated EPS (High)-3.900Full AccessFull AccessFull AccessFull Access
Estimated EPS (Low)-3.900Full AccessFull AccessFull AccessFull Access
Number of Analysts (Estimated Revenue)4Full AccessFull AccessFull AccessFull Access
Number of Analysts (Estimated EPS)4Full AccessFull AccessFull AccessFull Access

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(* All numbers are in thousands)

Current Key Metrics

?Revenue
 (TTM)
: 
  ?P/S
 (TTM)
: 
46.34
?Net Income
 (TTM)
: 
  ?P/E
 (TTM)
: 
-154.78
?Enterprise Value
 (TTM)
: 
4.107B  ?EV/FCF
 (TTM)
: 
-24.27
?Dividend Yield
 (TTM)
: 
0  ?Payout Ratio
 (TTM)
: 
0
?ROE
 (TTM)
: 
-0.29  ?ROIC
 (TTM)
: 
-0.29
?Net Debt
 (TTM)
: 
  ?Debt/Equity
 (TTM)
: 
0
?P/B
 (TTM)
: 
33.59  ?Current Ratio
 (TTM)
: 
13.25

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Forward P/E Ratios

?

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Forward P/E 1YFull AccessFull AccessFull AccessFull Access
N/AFull AccessFull AccessFull AccessFull Access

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SWOT Analysis

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At what price to buy it? -
Intrinsic Value Calculator

This is an automatic estimate. The most reliable way to know fair value for your own assumptions is to run the calculator below.


Calculate SYRE Intrinsic Value

Common questions about SYRE valuation

Is Spyre Therapeutics, Inc. (SYRE) overvalued or undervalued right now?

MARKETSnap estimates intrinsic value for Spyre Therapeutics, Inc. (SYRE) using its proprietary valuation methodology, which incorporates discounted cash flow (DCF) analysis together with long-term earnings and fundamentals assumptions. By comparing intrinsic value to the current market price, long-term investors can see whether the stock screens as potentially overvalued, fairly valued, or undervalued today.

Is SYRE a buy, hold, or sell for long-term investors?

MARKETSnap does not give one-word “buy” or “sell” calls. Instead, it shows whether SYRE trades at a premium or discount to its estimated intrinsic value, how sensitive that value is to growth and margin assumptions, and how the stock fits into a diversified, long-term portfolio so investors can make their own buy, hold, or sell decision.

What is SYRE’s P/E ratio?

You can see SYRE’s trailing P/E (TTM) and forward P/E estimates in the Current Key Metrics and Forward P/E Ratios sections above. The P/E ratio compares the current share price to earnings per share and helps investors gauge valuation relative to earnings.

How is intrinsic value calculated for SYRE?

MARKETSnap uses its own valuation framework—not a generic spreadsheet DCF alone. Future cash flows and earnings are projected, discounted, and combined with MARKETSnap’s methodology so intrinsic value reflects fundamentals and long-term assumptions. You can run your own inputs and see the result using the Intrinsic Value Calculator above.

Is SYRE a good long-term investment?

Whether SYRE fits a long-term portfolio depends on your assumptions about growth, margins, and risk. MARKETSnap provides the metrics, intrinsic value calculator, and SWOT context so you can form your own view rather than rely on a single buy/sell rating.

SYRE

1-day price chart preview. Log in for 1W through 5Y ranges and period tabs.

[ms_data_label text="Daily snapshot"]

-2.7
MARKETSnap

Trading Metrics:

[ms_session_rows_unavailable]
Open: [ms_cell_or_dash table='trading_quote' column='open']   Previous Close: [ms_cell_or_dash table='trading_quote' column='previousClose']
Day Low: [ms_cell_or_dash table='trading_quote' column='dayLow']   Day High: [ms_cell_or_dash table='trading_quote' column='dayHigh']
Year Low: 10.91   Year High: 51.06
Price Avg 50: 39.64   Price Avg 200: 26.25
Volume: 438009   Average Volume: 1.029M

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See in Nexus

Relevant news

Spyre Therapeutics Announces Grants of Inducement Awards
05-12-2025 16:05
Spyre Therapeutics Announces Grants of Inducement Awards
SYRE Stock Jumps More Than 70% in a Month: What Is Driving This Rally?
23-04-2026 13:36
SYRE Stock Jumps More Than 70% in a Month: What Is Driving This Rally?
16-04-2026 16:15
Spyre Therapeutics, Inc. Announces Closing of Public Offering and Full Exercise of the Underwriters' Option to Purchase Additional Shares for Gross Proceeds of $463.5 Million
14-04-2026 22:38
Spyre Therapeutics Announces Pricing of Upsized $403.0 Million Public Offering of Common Stock
13-04-2026 13:29
Spyre Therapeutics Breaks Higher On Positive Data From Ulcerative Colitis Drug
10-04-2026 16:05
Spyre Therapeutics to Host Conference Call to Report SPY001 Part A Induction Topline Results from SKYLINE Trial in Moderate-to-Severe Ulcerative Colitis Patients on April 13, 2026

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