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IONS stock logo

IONS

Ionis Pharmaceuticals, Inc.

$74.79
-0.34
 (-0.45%)
Exchange:  NASDAQ
Market Cap:  12.355B
Shares Outstanding:  6.429M
Overview
Earnings
Financials
Valuation
Chart

About The Company

Sector:  Healthcare
Industry:  Biotechnology
   
CEO:  Brett Monia
Full Time Employees:  1069
Address: 
2855 Gazelle Court
Carlsbad
CA
92010
US
Website:  https://www.ionispharma.com
Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an injection for the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; and WAYLIVRA, a treatment for familial chylomicronemia syndrome and familial partial lipodystrophy. It also develops medicines for various indications that are in phase 3 study, including Eplontersen as a monthly self-administered subcutaneous injection to treat all types of TTR amyloidosis; Olezarsen for patients with severe hypertriglyceridemia (SHTG); Donidalorsen for patients with hereditary angioedema; ION363 for patients with amyotrophic lateral sclerosis; Pelacarsen for patients with established cardiovascular disease and elevated lipoprotein(a); and Tofersen to inhibit the production of superoxide dismutase 1. In addition, the company develops medicines for metabolic diseases, infectious diseases, renal diseases, ophthalmic diseases, and cancer. It has a strategic collaboration with Biogen Inc.; and collaboration and license agreement with AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis AG, Roche, Janssen Biotech, Inc., and Flamingo Therapeutics, Inc. Ionis Pharmaceuticals, Inc. was founded in 1989 and is based in Carlsbad, California.

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Revenue Segmentation

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EPS

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Earnings Call

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Earnings transcript

Read the complete earnings call transcript.

AI summary

Key takeaways

Short, structured highlights from the call so you can focus on what matters.

2025/04/30 — Q1 quarter 2025

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Income Statement
Balance Sheet
Cash Flow Statement
Analyst Estimates

Income Statement

Year202320242025
Revenue787,647705,138944,000
Gross Profit778,514693,923928,000
EBITDA-235,870-353,721-286,745
Operating Income-353,730-475,081-382,000
Net Income-366,286-453,897-381,000

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(* All numbers are in thousands)

Balance Sheet

Year202320242025
Total Assets2,990,0723,003,6753,524,000
Total Liabilities2,603,3862,415,3243,035,000
Total Stockholders Equity386,686588,351489,000
Total Debt1,453,5391,416,5692,826,000
Cash and Cash Equivalents399,266242,077372,260

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Cash Flow Statement

Year202320242025
Operating Cash Flow-307,513-500,947-268,583
Capital Expenditure-28,011-45,280-51,444
Free Cash Flow-335,524-546,227-320,027
Net Income-366,286-453,897-381,387
Net Change in Cash122,794-157,189130,183

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(* All numbers are in thousands)

Analyst Estimates

Fiscal Year2030Full AccessFull AccessFull AccessFull Access
Estimated Revenue (Low)3,020,873.823Full AccessFull AccessFull AccessFull Access
Estimated Revenue (High)4,220,031.760Full AccessFull AccessFull AccessFull Access
Estimated Revenue (Avg)3,562,997.527Full AccessFull AccessFull AccessFull Access
Estimated Ebitda (Low)-1,265,176.399Full AccessFull AccessFull AccessFull Access
Estimated Ebitda (High)-905,665.759Full AccessFull AccessFull AccessFull Access
Estimated Ebitda (Avg)-1,068,195.843Full AccessFull AccessFull AccessFull Access
Estimated Net Income (Low)830,892.805Full AccessFull AccessFull AccessFull Access
Estimated Net Income (High)1,284,068.808Full AccessFull AccessFull AccessFull Access
Estimated Net Income (Avg)1,035,768.006Full AccessFull AccessFull AccessFull Access
Estimated SGA Expense (Low)941,781.188Full AccessFull AccessFull AccessFull Access
Estimated SGA Expense (High)1,315,628.112Full AccessFull AccessFull AccessFull Access
Estimated SGA Expense (Avg)1,110,792.519Full AccessFull AccessFull AccessFull Access
Estimated EPS (Avg)6.470Full AccessFull AccessFull AccessFull Access
Estimated EPS (High)8.030Full AccessFull AccessFull AccessFull Access
Estimated EPS (Low)5.190Full AccessFull AccessFull AccessFull Access
Number of Analysts (Estimated Revenue)13Full AccessFull AccessFull AccessFull Access
Number of Analysts (Estimated EPS)4Full AccessFull AccessFull AccessFull Access

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(* All numbers are in thousands)

Current Key Metrics

?Revenue
 (TTM)
: 
705.138M  ?P/S
 (TTM)
: 
13.26
?Net Income
 (TTM)
: 
-453897000  ?P/E
 (TTM)
: 
-32.19
?Enterprise Value
 (TTM)
: 
14.749B  ?EV/FCF
 (TTM)
: 
-46.09
?Dividend Yield
 (TTM)
: 
0  ?Payout Ratio
 (TTM)
: 
0
?ROE
 (TTM)
: 
-0.69  ?ROIC
 (TTM)
: 
-0.12
?Net Debt
 (TTM)
: 
-344138000  ?Debt/Equity
 (TTM)
: 
5.35
?P/B
 (TTM)
: 
25.08  ?Current Ratio
 (TTM)
: 
3.83

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Forward P/E Ratios

?

Forward P/E (Avg EPS estimate) — log in with Full Access for high/low estimates and the interactive table.

Forward P/E 1YFull AccessFull AccessFull AccessFull Access
N/AFull AccessFull AccessFull AccessFull Access

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SWOT Analysis

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At what price to buy it? -
Intrinsic Value Calculator

This is an automatic estimate. The most reliable way to know fair value for your own assumptions is to run the calculator below.


Calculate IONS Intrinsic Value

Common questions about IONS valuation

Is Ionis Pharmaceuticals, Inc. (IONS) overvalued or undervalued right now?

MARKETSnap estimates intrinsic value for Ionis Pharmaceuticals, Inc. (IONS) using its proprietary valuation methodology, which incorporates discounted cash flow (DCF) analysis together with long-term earnings and fundamentals assumptions. By comparing intrinsic value to the current market price, long-term investors can see whether the stock screens as potentially overvalued, fairly valued, or undervalued today.

Is IONS a buy, hold, or sell for long-term investors?

MARKETSnap does not give one-word “buy” or “sell” calls. Instead, it shows whether IONS trades at a premium or discount to its estimated intrinsic value, how sensitive that value is to growth and margin assumptions, and how the stock fits into a diversified, long-term portfolio so investors can make their own buy, hold, or sell decision.

What is IONS’s P/E ratio?

You can see IONS’s trailing P/E (TTM) and forward P/E estimates in the Current Key Metrics and Forward P/E Ratios sections above. The P/E ratio compares the current share price to earnings per share and helps investors gauge valuation relative to earnings.

How is intrinsic value calculated for IONS?

MARKETSnap uses its own valuation framework—not a generic spreadsheet DCF alone. Future cash flows and earnings are projected, discounted, and combined with MARKETSnap’s methodology so intrinsic value reflects fundamentals and long-term assumptions. You can run your own inputs and see the result using the Intrinsic Value Calculator above.

Is IONS a good long-term investment?

Whether IONS fits a long-term portfolio depends on your assumptions about growth, margins, and risk. MARKETSnap provides the metrics, intrinsic value calculator, and SWOT context so you can form your own view rather than rely on a single buy/sell rating.

IONS

1-day price chart preview. Log in for 1W through 5Y ranges and period tabs.

Daily snapshot

-0.45
MARKETSnap

Trading Metrics:

Open: 73.92   Previous Close: 75.13
Day Low: 73.35   Day High: 75.13
Year Low: 23.95   Year High: 86.74
Price Avg 50: 78.58   Price Avg 200: 66.28
Volume: 1.792M   Average Volume: 2.101M

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See in Nexus

Relevant news

Ionis Pharmaceuticals, Inc. $IONS Shares Sold by Aberdeen Group plc
10-04-2026 03:08
Ionis Pharmaceuticals, Inc. $IONS Shares Sold by Aberdeen Group plc
Assenagon Asset Management S.A. Cuts Stake in Ionis Pharmaceuticals, Inc. $IONS
31-03-2026 03:32
Assenagon Asset Management S.A. Cuts Stake in Ionis Pharmaceuticals, Inc. $IONS
Why Is Ionis Pharmaceuticals (IONS) Down 7.9% Since Last Earnings Report?
27-03-2026 12:31
Why Is Ionis Pharmaceuticals (IONS) Down 7.9% Since Last Earnings Report?
Ionis Pharmaceuticals' Peak Olezarsen Revenues Are Likely Very Conservative
20-03-2026 09:13
Ionis Pharmaceuticals' Peak Olezarsen Revenues Are Likely Very Conservative
Ionis Pharmaceuticals, Inc. (IONS) Presents at Stifel 2026 Virtual CNS Forum Transcript
17-03-2026 16:22
Ionis Pharmaceuticals, Inc. (IONS) Presents at Stifel 2026 Virtual CNS Forum Transcript
Ionis Pharmaceuticals, Inc. (IONS) Presents at Barclays 28th Annual Global Healthcare Conference Transcript
11-03-2026 16:12
Ionis Pharmaceuticals, Inc. (IONS) Presents at Barclays 28th Annual Global Healthcare Conference Transcript

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