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VRTX stock logo

VRTX

Vertex Pharmaceuticals Incorporated

$485.39
-11.11
 (-2.24%)
Exchange:  NASDAQ
Market Cap:  123.195B
Shares Outstanding:  13.03M
Delayed data
Calculate VRTX Intrinsic Value
5-year outlook →
Overview
Earnings
Financials
Valuation
Chart

About The Company

Sector:  Healthcare
Industry:  Biotechnology
   
CEO:  Reshma Kewalramani
Full Time Employees:  6100
Address: 
50 Northern Avenue
Boston
MA
2210
US
Website:  https://www.vrtx.com
Vertex Pharmaceuticals Incorporated is a leading biotechnology firm primarily focused on the discovery, advancement, and marketing of innovative treatments, particularly for cystic fibrosis (CF). The company offers a range of approved medications for CF patients, including SYMDEKO/SYMKEVI, ORKAMBI, and KALYDECO, which target specific mutations within the cystic fibrosis transmembrane conductance regulator gene. Additionally, they provide TRIKAFTA for individuals with CF aged six years and older who possess at least one F508del mutation. Beyond its established CF therapies, Vertex maintains a robust and diverse clinical pipeline. This includes VX-864, currently in Phase 2 for alpha-1 antitrypsin (AAT) deficiency; VX-147, also in Phase 2, addressing APOL1-mediated focal segmental glomerulosclerosis (FSGS) and other serious kidney conditions; VX-880, a potential treatment for Type 1 Diabetes undergoing Phase 1/2 trials; VX-548, a NaV1.8 inhibitor in Phase 2 for various forms of acute, neuropathic, and musculoskeletal pain; and CTX001, which is in Phase 3 development for severe sickle cell disease (SCD) and transfusion-dependent beta-thalassemia (TDT). The company distributes its pharmaceutical products through specialty pharmacies and distributors across the United States, while international sales are facilitated via a network of specialty distributors, retail chains, hospitals, and clinics. Vertex also engages in numerous strategic collaborations with partners such as Affinia Therapeutics, Arbor Biotechnologies, CRISPR Therapeutics, Kymera Therapeutics, Mammoth Biosciences, Moderna, Obsidian Therapeutics, Skyhawk Therapeutics, Ribometrix, Genomics plc, Merck KGaA, and X-Chem. Established in 1989, Vertex Pharmaceuticals is headquartered in Boston, Massachusetts.

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Revenue Segmentation

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EPS

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Earnings Call

Full text

Earnings transcript

Read the complete earnings call transcript.

AI summary

Key takeaways

Short, structured highlights from the call so you can focus on what matters.

2026/05/04 — Q1 quarter 2026

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Income Statement
Balance Sheet
Cash Flow Statement
Analyst Estimates

Income Statement

Year202320242025
Revenue9,869,20011,020,10012,074,600
Gross Profit8,607,0009,489,60010,267,500
EBITDA4,605,200486,3004,863,700
Operating Income3,832,000-232,9004,760,700
Net Income3,619,600-535,6003,953,200

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(* All numbers are in thousands)

Balance Sheet

Year202320242025
Total Assets22,730,20022,533,20025,643,000
Total Liabilities5,149,8006,123,6006,977,200
Total Stockholders Equity17,580,40016,409,60018,665,800
Total Debt808,4001,749,5003,693,000
Cash and Cash Equivalents10,369,1004,569,6005,084,800

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(* All numbers are in thousands)

Cash Flow Statement

Year202320242025
Operating Cash Flow3,537,300-492,6003,631,400
Capital Expenditure-258,399.999-297,700-437,600
Free Cash Flow3,278,900.001-790,3003,193,800
Net Income3,619,600-535,6003,953,200
Net Change in Cash-139,700-5,800,100515,600

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(* All numbers are in thousands)

Analyst Estimates

Fiscal Year2030Research AccessResearch AccessResearch AccessResearch Access
Estimated Revenue (Low)18,902,835.543Research AccessResearch AccessResearch AccessResearch Access
Estimated Revenue (High)21,045,278.624Research AccessResearch AccessResearch AccessResearch Access
Estimated Revenue (Avg)19,594,486.113Research AccessResearch AccessResearch AccessResearch Access
Estimated Ebitda (Low)6,787,602.759Research AccessResearch AccessResearch AccessResearch Access
Estimated Ebitda (High)7,556,908.112Research AccessResearch AccessResearch AccessResearch Access
Estimated Ebitda (Avg)7,035,959.643Research AccessResearch AccessResearch AccessResearch Access
Estimated Net Income (Low)8,246,113.471Research AccessResearch AccessResearch AccessResearch Access
Estimated Net Income (High)9,474,595.956Research AccessResearch AccessResearch AccessResearch Access
Estimated Net Income (Avg)8,642,708.493Research AccessResearch AccessResearch AccessResearch Access
Estimated SGA Expense (Low)2,305,862.735Research AccessResearch AccessResearch AccessResearch Access
Estimated SGA Expense (High)2,567,208.693Research AccessResearch AccessResearch AccessResearch Access
Estimated SGA Expense (Avg)2,390,233.742Research AccessResearch AccessResearch AccessResearch Access
Estimated EPS (Avg)33.500Research AccessResearch AccessResearch AccessResearch Access
Estimated EPS (High)36.720Research AccessResearch AccessResearch AccessResearch Access
Estimated EPS (Low)31.960Research AccessResearch AccessResearch AccessResearch Access
Number of Analysts (Estimated Revenue)12Research AccessResearch AccessResearch AccessResearch Access
Number of Analysts (Estimated EPS)12Research AccessResearch AccessResearch AccessResearch Access

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(* All numbers are in thousands)

Current Key Metrics

?Revenue
 (TTM)
: 
10.984B  ?P/S
 (TTM)
: 
10.05
?Net Income
 (TTM)
: 
-535600000  ?P/E
 (TTM)
: 
28.54
?Enterprise Value
 (TTM)
: 
119.688B  ?EV/FCF
 (TTM)
: 
32.26
?Dividend Yield
 (TTM)
: 
0%  ?Payout Ratio
 (TTM)
: 
0%
?ROE
 (TTM)
: 
23.93%  ?ROIC
 (TTM)
: 
17.74%
?Net Debt
 (TTM)
: 
-4369000000  ?Debt/Equity
 (TTM)
: 
0.1
?P/B
 (TTM)
: 
6.37  ?Current Ratio
 (TTM)
: 
3.02

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Forward P/E Ratios

?

Forward P/E (Avg EPS estimate) — log in with Research Access for high/low estimates and the interactive table.

Forward P/E 1YResearch AccessResearch AccessResearch AccessResearch Access
25.27Research AccessResearch AccessResearch AccessResearch Access

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SWOT Analysis

Strengths (preview)

  • Robust Financial Performance: Vertex Pharmaceuticals reported strong financial results in Q4 2024, with revenue and net income growth exceeding expectations, as highlighted in the earnings call transcript. Key metrics such as operating cash flow and free cash flow demonstrate solid liquidity and operational efficiency, supporting sustained growth.
  • Innovative Product Pipeline: The company emphasized advancements in its clinical pipeline during the Q4 2024 earnings call, with new product launches contributing to revenue growth. This focus on innovation aligns with industry trends in biotechnology, positioning VRTX as a leader in its sector.
  • Strong Profitability Metrics: High gross profit margin and net profit margin (TTM) reflect efficient cost management and profitability compared to industry averages, providing a competitive edge within the biotechnology sector.

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At what price to buy it? -
Intrinsic Value Calculator

This is an automatic estimate. The most reliable way to know fair value for your own assumptions is to run the calculator below.

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Common questions about VRTX valuation

Is Vertex Pharmaceuticals Incorporated (VRTX) overvalued or undervalued right now?

MARKETSnap estimates intrinsic value for Vertex Pharmaceuticals Incorporated (VRTX) using its proprietary valuation methodology, which incorporates discounted cash flow (DCF) analysis together with long-term earnings and fundamentals assumptions. By comparing intrinsic value to the current market price, long-term investors can see whether the stock screens as potentially overvalued, fairly valued, or undervalued today.

Is VRTX a buy, hold, or sell for long-term investors?

MARKETSnap does not give one-word “buy” or “sell” calls. Instead, it shows whether VRTX trades at a premium or discount to its estimated intrinsic value, how sensitive that value is to growth and margin assumptions, and how the stock fits into a diversified, long-term portfolio so investors can make their own buy, hold, or sell decision.

What is VRTX’s P/E ratio?

You can see VRTX’s trailing P/E (TTM) and forward P/E estimates in the Current Key Metrics and Forward P/E Ratios sections above. The P/E ratio compares the current share price to earnings per share and helps investors gauge valuation relative to earnings.

How is intrinsic value calculated for VRTX?

MARKETSnap uses its own valuation framework—not a generic spreadsheet DCF alone. Future cash flows and earnings are projected, discounted, and combined with MARKETSnap’s methodology so intrinsic value reflects fundamentals and long-term assumptions. You can run your own inputs and see the result using the Intrinsic Value Calculator above.

Is VRTX a good long-term investment?

Whether VRTX fits a long-term portfolio depends on your assumptions about growth, margins, and risk. MARKETSnap provides the metrics, intrinsic value calculator, and SWOT context so you can form your own view rather than rely on a single buy/sell rating.

VRTX

1-day price chart preview. Log in for 1W through 5Y ranges and period tabs.

Daily snapshot

-2.24
MARKETSnap

Trading Metrics:

Open: 498.15   Previous Close: 496.5
Day Low: 484.33   Day High: 498.91
Year Low: 362.5   Year High: 533.67
Price Avg 50: 453.27   Price Avg 200: 446.37
Volume: 1.423M   Average Volume: 1.483M

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VRTX full analysis

24/02/2026

Hey everyone, welcome back to the channel! Today, we’re diving deep into a comprehensive analysis of Vertex Pharmaceuticals, ticker VRTX, a powerhouse in the biotech space. If you’re looking to invest in a company that’s been making waves with its innovative therapies, stick around because we’re breaking down everything from financials to future potential. Let’s get started! So, why are we talking about Vertex Pharmaceuticals? Well, this isn’t just any biotech company—it’s a leader in developing treatments for serious diseases,…

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