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SLN stock logo

SLN

Silence Therapeutics plc

$5.94
0.47
 (8.59%)
Exchange:  NASDAQ
Market Cap:  280.57M
Shares Outstanding:  109933
Overview
Earnings
Financials
Valuation
Chart

About The Company

Sector:  Healthcare
Industry:  Biotechnology
   
CEO:  Iain Gladstone Ross
Full Time Employees:  116
Address: 
72 Hammersmith Road
London
W14 8TH
GB
Website:  https://www.silence-therapeutics.com
Silence Therapeutics plc, a biotechnology company, focuses on the discovery and development of novel ribonucleic acid (RNA) therapeutics in hematology, cardiovascular, and other rare and metabolic indications. The company’s platform includes mRNAi GalNAc Oligonucleotide Discovery platform designed to accurately target specific disease-associated genes in the liver. It designs short interfering RNA molecules to harness the body’s natural mechanism of RNA interference, and degrading messenger RNA molecules that encode specific targeted disease-associated proteins in a cell. The company is developing various product candidates, including SLN360, which is Phase I clinical trials for the treatment of cardiovascular disease with high lipoprotein; SLN124 that is in Phase I clinical trials for the treatment of non-transfusion dependent thalassemia, and Phase I clinical trials for the treatment of myelodysplastic syndrome; and SLN124 for the treatment of polycythemia vera. It has collaboration agreements with AstraZeneca PLC to discover, develop, and commercialize small interfering RNA therapeutics for the treatment of cardiovascular, renal, metabolic, and respiratory diseases; and Mallinckrodt Pharma IP Trading DAC to develop and commercialize RNAi drug targets designed to silence the complement cascade in complement-mediated disorders. The company also has a collaboration with Hansoh Pharmaceutical Group Company Limited to develop siRNAs for three undisclosed targets leveraging Silence’s mRNAi GOLD platform. The company was formerly known as SR Pharma plc and changed its name to Silence Therapeutics plc in May 2007. Silence Therapeutics plc is headquartered in London, the United Kingdom.

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Revenue Segmentation

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EPS

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Earnings Call

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Earnings transcript

Read the complete earnings call transcript.

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Key takeaways

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2025/02/28 — Q4 quarter 2024

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Income Statement
Balance Sheet
Cash Flow Statement
Analyst Estimates

Income Statement

Year202320242025
Revenue25,37543,258559
Gross Profit15,05731,448344
EBITDA-49,778-48,989-89,198
Operating Income-49,604-63,319-89,753
Net Income-43,267-45,309-88,612

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(* All numbers are in thousands)

Balance Sheet

Year202320242025
Total Assets93,822202,635131,442
Total Liabilities76,77268,61269,138
Total Stockholders Equity17,050134,02362,304
Total Debt272117-160
Cash and Cash Equivalents54,031121,33011,277

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Cash Flow Statement

Year202320242025
Operating Cash Flow-39,350-67,640-62,271
Capital Expenditure-45-211-55
Free Cash Flow-39,395-67,851-62,326
Net Income-50,310-36,190.110-88,612
Net Change in Cash-78552,541-81,676.934

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(* All numbers are in thousands)

Analyst Estimates

Fiscal Year2030Full AccessFull AccessFull AccessFull Access
Estimated Revenue (Low)2,135.611Full AccessFull AccessFull AccessFull Access
Estimated Revenue (High)553,405.501Full AccessFull AccessFull AccessFull Access
Estimated Revenue (Avg)168,900Full AccessFull AccessFull AccessFull Access
Estimated Ebitda (Low)-553,405.501Full AccessFull AccessFull AccessFull Access
Estimated Ebitda (High)-2,135.611Full AccessFull AccessFull AccessFull Access
Estimated Ebitda (Avg)-168,900Full AccessFull AccessFull AccessFull Access
Estimated Net Income (Low)-104,727.028Full AccessFull AccessFull AccessFull Access
Estimated Net Income (High)7,499.900Full AccessFull AccessFull AccessFull Access
Estimated Net Income (Avg)-26,449.678Full AccessFull AccessFull AccessFull Access
Estimated SGA Expense (Low)18,880.364Full AccessFull AccessFull AccessFull Access
Estimated SGA Expense (High)4,892,509.699Full AccessFull AccessFull AccessFull Access
Estimated SGA Expense (Avg)1,493,199.628Full AccessFull AccessFull AccessFull Access
Estimated EPS (Avg)-0.560Full AccessFull AccessFull AccessFull Access
Estimated EPS (High)0.160Full AccessFull AccessFull AccessFull Access
Estimated EPS (Low)-2.220Full AccessFull AccessFull AccessFull Access
Number of Analysts (Estimated Revenue)1Full AccessFull AccessFull AccessFull Access
Number of Analysts (Estimated EPS)1Full AccessFull AccessFull AccessFull Access

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(* All numbers are in thousands)

Current Key Metrics

?Revenue
 (TTM)
: 
  ?P/S
 (TTM)
: 
636.26
?Net Income
 (TTM)
: 
  ?P/E
 (TTM)
: 
-4.01
?Enterprise Value
 (TTM)
: 
344.235M  ?EV/FCF
 (TTM)
: 
-5.52
?Dividend Yield
 (TTM)
: 
0  ?Payout Ratio
 (TTM)
: 
0
?ROE
 (TTM)
: 
-3.01  ?ROIC
 (TTM)
: 
-0.77
?Net Debt
 (TTM)
: 
  ?Debt/Equity
 (TTM)
: 
0
?P/B
 (TTM)
: 
5.71  ?Current Ratio
 (TTM)
: 
8.72

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Forward P/E Ratios

?

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Forward P/E 1YFull AccessFull AccessFull AccessFull Access
N/AFull AccessFull AccessFull AccessFull Access

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SWOT Analysis

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Intrinsic Value Calculator

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Common questions about SLN valuation

Is Silence Therapeutics plc (SLN) overvalued or undervalued right now?

MARKETSnap estimates intrinsic value for Silence Therapeutics plc (SLN) using its proprietary valuation methodology, which incorporates discounted cash flow (DCF) analysis together with long-term earnings and fundamentals assumptions. By comparing intrinsic value to the current market price, long-term investors can see whether the stock screens as potentially overvalued, fairly valued, or undervalued today.

Is SLN a buy, hold, or sell for long-term investors?

MARKETSnap does not give one-word “buy” or “sell” calls. Instead, it shows whether SLN trades at a premium or discount to its estimated intrinsic value, how sensitive that value is to growth and margin assumptions, and how the stock fits into a diversified, long-term portfolio so investors can make their own buy, hold, or sell decision.

What is SLN’s P/E ratio?

You can see SLN’s trailing P/E (TTM) and forward P/E estimates in the Current Key Metrics and Forward P/E Ratios sections above. The P/E ratio compares the current share price to earnings per share and helps investors gauge valuation relative to earnings.

How is intrinsic value calculated for SLN?

MARKETSnap uses its own valuation framework—not a generic spreadsheet DCF alone. Future cash flows and earnings are projected, discounted, and combined with MARKETSnap’s methodology so intrinsic value reflects fundamentals and long-term assumptions. You can run your own inputs and see the result using the Intrinsic Value Calculator above.

Is SLN a good long-term investment?

Whether SLN fits a long-term portfolio depends on your assumptions about growth, margins, and risk. MARKETSnap provides the metrics, intrinsic value calculator, and SWOT context so you can form your own view rather than rely on a single buy/sell rating.

SLN

1-day price chart preview. Log in for 1W through 5Y ranges and period tabs.

Daily snapshot

8.59
MARKETSnap

Trading Metrics:

Open: 5.52   Previous Close: 5.47
Day Low: 5.26   Day High: 5.94
Year Low: 1.97   Year High: 7.91
Price Avg 50: 5.46   Price Avg 200: 5.82
Volume: 285642   Average Volume: 305839

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See in Nexus

Relevant news

Silence Therapeutics Announces Leadership Changes
15-12-2025 08:13
Silence Therapeutics Announces Leadership Changes

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