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APLS stock logo

APLS

Apellis Pharmaceuticals, Inc.

$41.03
0
 (0%)
Exchange:  NASDAQ
Market Cap:  5.253B
Shares Outstanding:  18.093M
Delayed data
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Overview
Earnings
Financials
Valuation
Chart

About The Company

Sector:  Healthcare
Industry:  Biotechnology
   
CEO:  Cedric Francois
Full Time Employees:  705
Address: 
100 Fifth Avenue
Waltham
MA
2451
US
Website:  https://www.apellis.com
Apellis Pharmaceuticals, Inc. is an actively operating biopharmaceutical enterprise dedicated to the discovery, advancement, and commercialization of therapeutic agents. Its core strategy involves modulating the complement system to address various autoimmune and inflammatory conditions. The company’s primary investigational compound, pegcetacoplan, is currently undergoing Phase III clinical evaluation. This advanced-stage therapy is being explored for its potential in treating geographic atrophy (GA), a form of age-related macular degeneration, and paroxysmal nocturnal hemoglobinuria (PNH). Beyond this lead candidate, Apellis also offers EMPAVELI (a systemic formulation of pegcetacoplan), which is being developed for a range of indications: in hematology for cold agglutinin disease (CAD) and thrombotic microangiopathy associated with hematopoietic stem cell transplantation (HSCT-TMA); in nephrology for C3 glomerulopathy (C3G) and immune complex membranoproliferative glomerulonephritis (IC-MPGN); and in neurology for amyotrophic lateral sclerosis (ALS). Furthermore, Apellis boasts a diverse pipeline including APL-2006, a dual-action C3 and VEGF inhibitor designed for complement-mediated disorders; APL-1030, a C3 inhibitor targeting multiple neurodegenerative diseases; and a novel combination therapy involving EMPAVELI with small interfering RNA (siRNA) to reduce hepatic C3 protein synthesis. Strategic alliances play a significant role, with a collaboration and licensing agreement in place with Swedish Orphan Biovitrum AB (publ) for the joint development of pegcetacoplan. The company also maintains a research partnership with Beam Therapeutics Inc., focusing on leveraging Beam’s base editing technology to uncover new treatments for illnesses driven by complement system dysregulation. Established in 2009, Apellis Pharmaceuticals, Inc. operates from its headquarters in Waltham, Massachusetts.

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Revenue Segmentation

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EPS

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Earnings Call

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Earnings transcript

Read the complete earnings call transcript.

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Key takeaways

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2025/05/07 — Q1 quarter 2025

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Income Statement
Balance Sheet
Cash Flow Statement
Analyst Estimates

Income Statement

Year202320242025
Revenue396,591781,3671,003,782
Gross Profit338,081663,644901,546
EBITDA-495,211-154,52869,995
Operating Income-517,121-164,97955,427
Net Income-528,628-197,87822,388

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(* All numbers are in thousands)

Balance Sheet

Year202320242025
Total Assets788,730885,0511,075,257
Total Liabilities594,209656,512705,110
Total Stockholders Equity194,521228,539370,147
Total Debt110,928469,784112,696
Cash and Cash Equivalents351,185411,290466,233

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Cash Flow Statement

Year202320242025
Operating Cash Flow-594,735-87,86645,327
Capital Expenditure-773-4030
Free Cash Flow-595,508-88,26945,327
Net Income-528,628-197,87822,388
Net Change in Cash-200,77560,31355,148

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(* All numbers are in thousands)

Analyst Estimates

Fiscal Year2030Full AccessFull AccessFull AccessFull Access
Estimated Revenue (Low)1,380,273.377Full AccessFull AccessFull AccessFull Access
Estimated Revenue (High)1,716,514.769Full AccessFull AccessFull AccessFull Access
Estimated Revenue (Avg)1,536,472.692Full AccessFull AccessFull AccessFull Access
Estimated Ebitda (Low)-1,073,863.636Full AccessFull AccessFull AccessFull Access
Estimated Ebitda (High)-863,508.671Full AccessFull AccessFull AccessFull Access
Estimated Ebitda (Avg)-961,228.054Full AccessFull AccessFull AccessFull Access
Estimated Net Income (Low)277,039.821Full AccessFull AccessFull AccessFull Access
Estimated Net Income (High)367,857.757Full AccessFull AccessFull AccessFull Access
Estimated Net Income (Avg)319,228.876Full AccessFull AccessFull AccessFull Access
Estimated SGA Expense (Low)2,424,524.027Full AccessFull AccessFull AccessFull Access
Estimated SGA Expense (High)3,015,150.020Full AccessFull AccessFull AccessFull Access
Estimated SGA Expense (Avg)2,698,896.480Full AccessFull AccessFull AccessFull Access
Estimated EPS (Avg)2.530Full AccessFull AccessFull AccessFull Access
Estimated EPS (High)2.920Full AccessFull AccessFull AccessFull Access
Estimated EPS (Low)2.200Full AccessFull AccessFull AccessFull Access
Number of Analysts (Estimated Revenue)6Full AccessFull AccessFull AccessFull Access
Number of Analysts (Estimated EPS)5Full AccessFull AccessFull AccessFull Access

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(* All numbers are in thousands)

Current Key Metrics

?Revenue
 (TTM)
: 
781.367M  ?P/S
 (TTM)
: 
4.75
?Net Income
 (TTM)
: 
-197878000  ?P/E
 (TTM)
: 
38.8
?Enterprise Value
 (TTM)
: 
5.322B  ?EV/FCF
 (TTM)
: 
140.87
?Dividend Yield
 (TTM)
: 
0  ?Payout Ratio
 (TTM)
: 
0
?ROE
 (TTM)
: 
0.4  ?ROIC
 (TTM)
: 
0.18
?Net Debt
 (TTM)
: 
57.172M  ?Debt/Equity
 (TTM)
: 
1.15
?P/B
 (TTM)
: 
12.46  ?Current Ratio
 (TTM)
: 
3.63

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Forward P/E Ratios

?

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Forward P/E 1YFull AccessFull AccessFull AccessFull Access
N/AFull AccessFull AccessFull AccessFull Access

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SWOT Analysis

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Intrinsic Value Calculator

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Common questions about APLS valuation

Is Apellis Pharmaceuticals, Inc. (APLS) overvalued or undervalued right now?

MARKETSnap estimates intrinsic value for Apellis Pharmaceuticals, Inc. (APLS) using its proprietary valuation methodology, which incorporates discounted cash flow (DCF) analysis together with long-term earnings and fundamentals assumptions. By comparing intrinsic value to the current market price, long-term investors can see whether the stock screens as potentially overvalued, fairly valued, or undervalued today.

Is APLS a buy, hold, or sell for long-term investors?

MARKETSnap does not give one-word “buy” or “sell” calls. Instead, it shows whether APLS trades at a premium or discount to its estimated intrinsic value, how sensitive that value is to growth and margin assumptions, and how the stock fits into a diversified, long-term portfolio so investors can make their own buy, hold, or sell decision.

What is APLS’s P/E ratio?

You can see APLS’s trailing P/E (TTM) and forward P/E estimates in the Current Key Metrics and Forward P/E Ratios sections above. The P/E ratio compares the current share price to earnings per share and helps investors gauge valuation relative to earnings.

How is intrinsic value calculated for APLS?

MARKETSnap uses its own valuation framework—not a generic spreadsheet DCF alone. Future cash flows and earnings are projected, discounted, and combined with MARKETSnap’s methodology so intrinsic value reflects fundamentals and long-term assumptions. You can run your own inputs and see the result using the Intrinsic Value Calculator above.

Is APLS a good long-term investment?

Whether APLS fits a long-term portfolio depends on your assumptions about growth, margins, and risk. MARKETSnap provides the metrics, intrinsic value calculator, and SWOT context so you can form your own view rather than rely on a single buy/sell rating.

APLS

1-day price chart preview. Log in for 1W through 5Y ranges and period tabs.

Daily snapshot

0
MARKETSnap

Trading Metrics:

Open: 41.05   Previous Close: 41.03
Day Low: 41.03   Day High: 41.05
Year Low: 16.61   Year High: 41.14
Price Avg 50: 33.6   Price Avg 200: 26.15
Volume: 28.643M   Average Volume: 6.374M

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See in Nexus

Relevant news

Compared to Estimates, Apellis Pharmaceuticals (APLS) Q1 Earnings: A Look at Key Metrics
07-05-2026 17:00
Compared to Estimates, Apellis Pharmaceuticals (APLS) Q1 Earnings: A Look at Key Metrics
Apellis Pharmaceuticals, Inc. (NASDAQ:APLS) Given Average Rating of “Hold” by Analysts
10-04-2026 03:18
Apellis Pharmaceuticals, Inc. (NASDAQ:APLS) Given Average Rating of “Hold” by Analysts
SHAREHOLDER ALERT: The M&A Class Action Firm Announces An Investigation of Apellis Pharmaceuticals, Inc. (NASDAQ: APLS)
01-04-2026 16:07
SHAREHOLDER ALERT: The M&A Class Action Firm Announces An Investigation of Apellis Pharmaceuticals, Inc. (NASDAQ: APLS)
Apellis Pharmaceuticals (APLS) Moves 135.4% Higher: Will This Strength Last?
01-04-2026 08:55
Apellis Pharmaceuticals (APLS) Moves 135.4% Higher: Will This Strength Last?
Why This Pharma Stock More Than Doubled Today
31-03-2026 09:41
Why This Pharma Stock More Than Doubled Today
Why Is Apellis Pharmaceuticals (APLS) Down 17.3% Since Last Earnings Report?
26-03-2026 12:32
Why Is Apellis Pharmaceuticals (APLS) Down 17.3% Since Last Earnings Report?

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