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LYEL stock logo

LYEL

Lyell Immunopharma, Inc.

$14.81
0.01
 (0.07%)
Exchange:  NASDAQ
Market Cap:  362.91M
Shares Outstanding:  12.329M
Delayed data
Calculate LYEL Intrinsic Value
5-year outlook →
Overview
Earnings
Financials
Valuation
Chart

About The Company

Sector:  Healthcare
Industry:  Biotechnology
   
CEO:  Lynn Seely
Full Time Employees:  161
Address: 
201 Haskins Way
South San Francisco
CA
94080
US
Website:  https://www.lyell.com
Lyell Immunopharma, Inc., a clinical-stage cell therapy company, develops chimeric antigen receptor (CAR) T-cell product candidates for patients with hematologic malignancies and solid tumors. The company’s lead product candidate include rondecabtagene autoleucel, an autologous dual-targeting CD19/CD20 CAR T-cell therapy in development, which is in pivotal PiNACLE trial in the 3L+ setting and in a Phase 1/2 clinical trial in the 2L setting, as well as a second pivotal trial, PiNACLE-H2H, which is a Phase 3 head-to-head CAR T cell therapy randomized controlled trial of ronde-cel for LBCL in the 2L setting for the treatment of large B-cell lymphoma; and LYL273, a GCC-targeted CAR T-cell product candidate enhanced with CD19 CAR expression and controlled cytokine release designed to improve CAR T-cell expansion, immune cell infiltration, and cancer cell killing in the hostile solid tumor microenvironment, which is in Phase 1 clinical trial for the treatment of refractory metastatic colorectal cancer. The company develops therapies using various approaches, such as c-Jun overexpression and NR4A3 gene knockout, to endow functional resistance to exhaustion; Epi-R to generate population of stem-like T cells with reduced exhaustion and improved proliferation and antitumor activity; and CD62L positive enrichment to generate CAR T cells with enhanced antitumor activity. Lyell Immunopharma, Inc. was incorporated in 2018 and is headquartered in South San Francisco, California.

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Revenue Segmentation

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EPS

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Earnings Call

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Income Statement
Balance Sheet
Cash Flow Statement
Analyst Estimates

Income Statement

Year202320242025
Revenue1306136
Gross Profit13061-11,503
EBITDA-214,382-200,643-262,909
Operating Income-247,008-358,755-203,774
Net Income-234,632-342,994-274,448

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(* All numbers are in thousands)

Balance Sheet

Year202320242025
Total Assets750,029490,859340,052
Total Liabilities95,077108,03591,850
Total Stockholders Equity654,952382,824248,202
Total Debt63,16758,96841,921
Cash and Cash Equivalents145,647105,59760,181

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(* All numbers are in thousands)

Cash Flow Statement

Year202320242025
Operating Cash Flow-163,694-162,394-150,024
Capital Expenditure-2,686-464-780
Free Cash Flow-166,380-162,858-150,804
Net Income-234,632-342,994-274,448
Net Change in Cash22,097-38,644-45,521

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(* All numbers are in thousands)

Analyst Estimates

Fiscal Year2030Research AccessResearch AccessResearch AccessResearch Access
Estimated Revenue (Low)20,825.633Research AccessResearch AccessResearch AccessResearch Access
Estimated Revenue (High)552,429.915Research AccessResearch AccessResearch AccessResearch Access
Estimated Revenue (Avg)273,009.750Research AccessResearch AccessResearch AccessResearch Access
Estimated Ebitda (Low)-552,429.915Research AccessResearch AccessResearch AccessResearch Access
Estimated Ebitda (High)-20,825.633Research AccessResearch AccessResearch AccessResearch Access
Estimated Ebitda (Avg)-273,009.750Research AccessResearch AccessResearch AccessResearch Access
Estimated Net Income (Low)-136,636.322Research AccessResearch AccessResearch AccessResearch Access
Estimated Net Income (High)11,774.684Research AccessResearch AccessResearch AccessResearch Access
Estimated Net Income (Avg)-58,628.993Research AccessResearch AccessResearch AccessResearch Access
Estimated SGA Expense (Low)10,962,123.399Research AccessResearch AccessResearch AccessResearch Access
Estimated SGA Expense (High)290,786,114.307Research AccessResearch AccessResearch AccessResearch Access
Estimated SGA Expense (Avg)143,705,911.310Research AccessResearch AccessResearch AccessResearch Access
Estimated EPS (Avg)-3.430Research AccessResearch AccessResearch AccessResearch Access
Estimated EPS (High)0.690Research AccessResearch AccessResearch AccessResearch Access
Estimated EPS (Low)-7.990Research AccessResearch AccessResearch AccessResearch Access
Number of Analysts (Estimated Revenue)2Research AccessResearch AccessResearch AccessResearch Access
Number of Analysts (Estimated EPS)1Research AccessResearch AccessResearch AccessResearch Access

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(* All numbers are in thousands)

Current Key Metrics

?Revenue
 (TTM)
: 
61000  ?P/S
 (TTM)
: 
14094.54
?Net Income
 (TTM)
: 
-342994000  ?P/E
 (TTM)
: 
-0.97
?Enterprise Value
 (TTM)
: 
344.502M  ?EV/FCF
 (TTM)
: 
-2.57
?Dividend Yield
 (TTM)
: 
0%  ?Payout Ratio
 (TTM)
: 
0%
?ROE
 (TTM)
: 
-91.62%  ?ROIC
 (TTM)
: 
-70.8%
?Net Debt
 (TTM)
: 
-311559000  ?Debt/Equity
 (TTM)
: 
0.16
?P/B
 (TTM)
: 
1.55  ?Current Ratio
 (TTM)
: 
5.36

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Forward P/E Ratios

?

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Forward P/E 1YResearch AccessResearch AccessResearch AccessResearch Access
N/AResearch AccessResearch AccessResearch AccessResearch Access

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SWOT Analysis

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At what price to buy it? -
Intrinsic Value Calculator

This is an automatic estimate. The most reliable way to know fair value for your own assumptions is to run the calculator below.

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Common questions about LYEL valuation

Is Lyell Immunopharma, Inc. (LYEL) overvalued or undervalued right now?

MARKETSnap estimates intrinsic value for Lyell Immunopharma, Inc. (LYEL) using its proprietary valuation methodology, which incorporates discounted cash flow (DCF) analysis together with long-term earnings and fundamentals assumptions. By comparing intrinsic value to the current market price, long-term investors can see whether the stock screens as potentially overvalued, fairly valued, or undervalued today.

Is LYEL a buy, hold, or sell for long-term investors?

MARKETSnap does not give one-word “buy” or “sell” calls. Instead, it shows whether LYEL trades at a premium or discount to its estimated intrinsic value, how sensitive that value is to growth and margin assumptions, and how the stock fits into a diversified, long-term portfolio so investors can make their own buy, hold, or sell decision.

What is LYEL’s P/E ratio?

You can see LYEL’s trailing P/E (TTM) and forward P/E estimates in the Current Key Metrics and Forward P/E Ratios sections above. The P/E ratio compares the current share price to earnings per share and helps investors gauge valuation relative to earnings.

How is intrinsic value calculated for LYEL?

MARKETSnap uses its own valuation framework—not a generic spreadsheet DCF alone. Future cash flows and earnings are projected, discounted, and combined with MARKETSnap’s methodology so intrinsic value reflects fundamentals and long-term assumptions. You can run your own inputs and see the result using the Intrinsic Value Calculator above.

Is LYEL a good long-term investment?

Whether LYEL fits a long-term portfolio depends on your assumptions about growth, margins, and risk. MARKETSnap provides the metrics, intrinsic value calculator, and SWOT context so you can form your own view rather than rely on a single buy/sell rating.

LYEL

1-day price chart preview. Log in for 1W through 5Y ranges and period tabs.

Daily snapshot

0.07
MARKETSnap

Trading Metrics:

Open: 14.65   Previous Close: 14.8
Day Low: 14.39   Day High: 15.02
Year Low: 10.76   Year High: 45
Price Avg 50: 13.78   Price Avg 200: 20.4
Volume: 53677   Average Volume: 152972

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See in Nexus

Relevant news

This Lyell Immunopharma Analyst Begins Coverage On A Bullish Note; Here Are Top 3 Initiations For Thursday
06-08-2026 10:12
This Lyell Immunopharma Analyst Begins Coverage On A Bullish Note; Here Are Top 3 Initiations For Thursday
Lyell Immunopharma Presents Updated Safety Data and Translational Insights for Rondecabtagene Autoleucel (Ronde-Cel) in Patients with Large B-Cell Lymphoma at European Hematology Association 2026 Cong
12-06-2026 12:45
Lyell Immunopharma Presents Updated Safety Data and Translational Insights for Rondecabtagene Autoleucel (Ronde-Cel) in Patients with Large B-Cell Lymphoma at European Hematology Association 2026 Cong
Lyell Immunopharma Provides Update on Safety Profile of LYL273 in Relapsed or Refractory Metastatic Colorectal Cancer and Amends Phase 1 Trial to Phase 1/2 Expansion
08-06-2026 06:00
Lyell Immunopharma Provides Update on Safety Profile of LYL273 in Relapsed or Refractory Metastatic Colorectal Cancer and Amends Phase 1 Trial to Phase 1/2 Expansion
Lyell Immunopharma to Present Phase 1/2 Safety and Translational Data for Ronde-Cel in Large B-Cell Lymphoma at the European Hematology Association 2026 Congress
04-06-2026 16:05
Lyell Immunopharma to Present Phase 1/2 Safety and Translational Data for Ronde-Cel in Large B-Cell Lymphoma at the European Hematology Association 2026 Congress
Lyell Immunopharma, Inc. (LYEL) Presents at H.C. Wainwright 4th Annual BioConnect Investor Conference Transcript
22-05-2026 19:10
Lyell Immunopharma, Inc. (LYEL) Presents at H.C. Wainwright 4th Annual BioConnect Investor Conference Transcript
Head to Head Analysis: Lyell Immunopharma (NASDAQ:LYEL) & Mangoceuticals (NASDAQ:MGRX)
06-04-2026 01:24
Head to Head Analysis: Lyell Immunopharma (NASDAQ:LYEL) & Mangoceuticals (NASDAQ:MGRX)

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