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UPB

UPB

Upstream Bio, Inc.

$6.88
-0.25
 (-3.51%)
Exchange:  NASDAQ
Market Cap:  374.41M
Shares Outstanding:  36.323M
Delayed data
Calculate UPB Intrinsic Value
5-year outlook →
Overview
Earnings
Financials
Valuation
Chart

About The Company

Sector:  Healthcare
Industry:  Biotechnology
   
CEO:  E. Rand Sutherland
Full Time Employees:  75
Address: 
890 Winter Street
Waltham
MA
2451
US
Website:  https://upstreambio.com
Upstream Bio, Inc. is a biotechnology company in the clinical development stage, dedicated to innovating therapies for inflammatory conditions, particularly those affecting the severe respiratory system. Its pipeline notably features verekitug, a monoclonal antibody designed to selectively target and suppress the thymic stromal lymphopoietin receptor. Beyond this, the company is actively developing treatments for severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. Established in 2021, Upstream Bio maintains its operational base in Waltham, Massachusetts.

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Revenue Segmentation

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EPS

Historical EPS and analyst estimates in one chart. Log in for the full interactive view and links to detailed estimates.

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Earnings Call

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Income Statement
Balance Sheet
Cash Flow Statement
Analyst Estimates

Income Statement

Year202320242025
Revenue2,3802,3702,854
Gross Profit2,3802,3702,854
EBITDA-20,477-62,717-143,255
Operating Income-40,114-77,764-160,361
Net Income-20,537-62,806-143,443

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(* All numbers are in thousands)

Balance Sheet

Year202320242025
Total Assets117,198481,719353,772
Total Liabilities240,32411,86714,001
Total Stockholders Equity-123,126469,852339,771
Total Debt451,8341,269
Cash and Cash Equivalents25,833325,892101,578

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(* All numbers are in thousands)

Cash Flow Statement

Year202320242025
Operating Cash Flow-37,926-59,172-133,275
Capital Expenditure-144-511-165
Free Cash Flow-38,070-59,683-133,275
Net Income-20,537-62,806-143,443
Net Change in Cash8,782300,253-224,314

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(* All numbers are in thousands)

Analyst Estimates

Fiscal Year2030Research AccessResearch AccessResearch AccessResearch Access
Estimated Revenue (Low)47,551.623Research AccessResearch AccessResearch AccessResearch Access
Estimated Revenue (High)90,173.951Research AccessResearch AccessResearch AccessResearch Access
Estimated Revenue (Avg)72,804.750Research AccessResearch AccessResearch AccessResearch Access
Estimated Ebitda (Low)-90,173.951Research AccessResearch AccessResearch AccessResearch Access
Estimated Ebitda (High)-47,551.623Research AccessResearch AccessResearch AccessResearch Access
Estimated Ebitda (Avg)-72,804.750Research AccessResearch AccessResearch AccessResearch Access
Estimated Net Income (Low)-192,791.240Research AccessResearch AccessResearch AccessResearch Access
Estimated Net Income (High)-80,798.516Research AccessResearch AccessResearch AccessResearch Access
Estimated Net Income (Avg)-147,152.647Research AccessResearch AccessResearch AccessResearch Access
Estimated SGA Expense (Low)312,940.099Research AccessResearch AccessResearch AccessResearch Access
Estimated SGA Expense (High)593,440.211Research AccessResearch AccessResearch AccessResearch Access
Estimated SGA Expense (Avg)479,132.452Research AccessResearch AccessResearch AccessResearch Access
Estimated EPS (Avg)-2.730Research AccessResearch AccessResearch AccessResearch Access
Estimated EPS (High)-1.500Research AccessResearch AccessResearch AccessResearch Access
Estimated EPS (Low)-3.580Research AccessResearch AccessResearch AccessResearch Access
Number of Analysts (Estimated Revenue)5Research AccessResearch AccessResearch AccessResearch Access
Number of Analysts (Estimated EPS)4Research AccessResearch AccessResearch AccessResearch Access

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(* All numbers are in thousands)

Current Key Metrics

?Revenue
 (TTM)
: 
2.38M  ?P/S
 (TTM)
: 
120.11
?Net Income
 (TTM)
: 
-20537000  ?P/E
 (TTM)
: 
-2.4
?Enterprise Value
 (TTM)
: 
300.864M  ?EV/FCF
 (TTM)
: 
-2.21
?Dividend Yield
 (TTM)
: 
0%  ?Payout Ratio
 (TTM)
: 
0%
?ROE
 (TTM)
: 
-48.4%  ?ROIC
 (TTM)
: 
-62.52%
?Net Debt
 (TTM)
: 
-218718000  ?Debt/Equity
 (TTM)
: 
0
?P/B
 (TTM)
: 
1.4  ?Current Ratio
 (TTM)
: 
27.99

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Forward P/E Ratios

?

Forward P/E (Avg EPS estimate) — log in with Research Access for high/low estimates and the interactive table.

Forward P/E 1YResearch AccessResearch AccessResearch AccessResearch Access
N/AResearch AccessResearch AccessResearch AccessResearch Access

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SWOT Analysis

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At what price to buy it? -
Intrinsic Value Calculator

This is an automatic estimate. The most reliable way to know fair value for your own assumptions is to run the calculator below.

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Common questions about UPB valuation

Is Upstream Bio, Inc. (UPB) overvalued or undervalued right now?

MARKETSnap estimates intrinsic value for Upstream Bio, Inc. (UPB) using its proprietary valuation methodology, which incorporates discounted cash flow (DCF) analysis together with long-term earnings and fundamentals assumptions. By comparing intrinsic value to the current market price, long-term investors can see whether the stock screens as potentially overvalued, fairly valued, or undervalued today.

Is UPB a buy, hold, or sell for long-term investors?

MARKETSnap does not give one-word “buy” or “sell” calls. Instead, it shows whether UPB trades at a premium or discount to its estimated intrinsic value, how sensitive that value is to growth and margin assumptions, and how the stock fits into a diversified, long-term portfolio so investors can make their own buy, hold, or sell decision.

What is UPB’s P/E ratio?

You can see UPB’s trailing P/E (TTM) and forward P/E estimates in the Current Key Metrics and Forward P/E Ratios sections above. The P/E ratio compares the current share price to earnings per share and helps investors gauge valuation relative to earnings.

How is intrinsic value calculated for UPB?

MARKETSnap uses its own valuation framework—not a generic spreadsheet DCF alone. Future cash flows and earnings are projected, discounted, and combined with MARKETSnap’s methodology so intrinsic value reflects fundamentals and long-term assumptions. You can run your own inputs and see the result using the Intrinsic Value Calculator above.

Is UPB a good long-term investment?

Whether UPB fits a long-term portfolio depends on your assumptions about growth, margins, and risk. MARKETSnap provides the metrics, intrinsic value calculator, and SWOT context so you can form your own view rather than rely on a single buy/sell rating.

UPB

1-day price chart preview. Log in for 1W through 5Y ranges and period tabs.

Daily snapshot

-3.51
MARKETSnap

Trading Metrics:

Open: 7.11   Previous Close: 7.13
Day Low: 6.8   Day High: 7.14
Year Low: 5.85   Year High: 33.68
Price Avg 50: 6.89   Price Avg 200: 14.51
Volume: 112836   Average Volume: 591328

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See in Nexus

Relevant news

Upstream Bio, Inc. (UPB) Reports Q2 Loss, Tops Revenue Estimates
11-08-2026 09:36
Upstream Bio, Inc. (UPB) Reports Q2 Loss, Tops Revenue Estimates
Upstream Bio, Inc. (UPB) Upgraded to Buy: What Does It Mean for the Stock?
14-07-2026 13:01
Upstream Bio, Inc. (UPB) Upgraded to Buy: What Does It Mean for the Stock?
Upstream Bio, Inc. (UPB) Reports Q1 Loss, Beats Revenue Estimates
13-05-2026 09:20
Upstream Bio, Inc. (UPB) Reports Q1 Loss, Beats Revenue Estimates

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